Catheter Ablation Targeting Complex Fractionated Atrial Electrogram in Atrial Fibrillation.

The role of fibroblasts in complex fractionated electrograms during persistent/permanent atrial fibrillation: implications for electrogram-based catheter ablation.

RATIONALE Electrogram-based catheter ablation, targeting complex fractionated atrial electrograms (CFAEs), is empirically known to be effective in halting persistent/permanent atrial fibrillation (AF). However, the mechanisms underlying CFAEs and electrogram-based ablation remain unclear. OBJECTIVE Because atrial fibrosis is associated with persistent/permanent AF, we hypothesized that electr...

Scenes from a CFAE: Complex Fractionated Atrial Electrogram Map in a Woman with Longstanding Persistent Atrial Fibrillation Following Mechanical Mitral Valve Replacement.

Case: A 62-year-old woman was referred for atrial fibrillation (AF) ablation. She had longstanding persistent AF for 8 years since mechanical mitral valve replacement for rheumatic heart disease. EPS: A strategy of substrate-based ablation targeting areas of complex fractionated atrial electrograms (CFAE) was pursued. These sites were identified by inspection of electrograms and verified with s...

Catheter Ablation of Persistent Atrial Fibrillation

Catheter ablation for symptomatic, drug-resistant atrial fibrillation (AF) has become an important therapeutic option over the past decade. Pulmonary vein isolation (PVI) has been established as the cornerstone for ablation of paroxysmal AF. However, there is a dearth of data regarding the ideal approach for patients with persistent AF. It is generally accepted that PVI alone is insufficient fo...

Complex Fractionated Atrial Electrograms in Catheter Ablation of Atrial Fibrillation: Dead and Buried?

Is There Still a Role for Complex Fractionated Atrial Electrogram Ablation in Addition to Pulmonary Vein Isolation in Patients With Paroxysmal and Persistent Atrial Fibrillation?: Meta-Analysis of 1415 Patients Rui Providência, MD, MSc; Pier D. Lambiase, PhD; Neil Srinivasan, MD; Girish Ganesh Babu, MD; Konstantinos Bronis, MD; Syed Ahsan, MD; Fakhar Z. Khan, MD; Anthony W. Chow, MD; Edward Row...

Integrative Physiology The Role of Fibroblasts in Complex Fractionated Electrograms During Persistent/Permanent Atrial Fibrillation Implications for Electrogram-Based Catheter Ablation